Ingredients of the mRNA Covid-19 Vaccine

Ingredients of the mRNA Covid-19 Vaccine

Pfizer BioNTech COVID-19 vaccine is a nucleoside-modified messenger RNA vaccine (mRNA) vaccine. mRNA vaccines use the pathogen’s genetic code as the vaccine; this then exploits the host cells to translate the code and then make the target spike protein. The protein then acts as an intracellular antigen to stimulate the immune response. The mRNA is then normally degraded within a few days.

Pfizer BioNTech COVID-19 vaccine has been generated entirely in the laboratory, outside of living cells, formulated in lipid nanoparticles. The vaccine contains the following ingredients:

  • mRNA (messenger ribonucleic acid = a single-stranded RNA molecule that is complementary to one of the DNA strands of a gene).  
  • Lipids / fats
    ALC-0315 = (4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), – ALC-0159 = 2[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide, – 1,2-Distearoyl-sn-glycero-3-phosphocholine, 5 – cholesterol,
  • Salts
    – potassium chloride, – potassium dihydrogen phosphate, – sodium chloride, – disodium hydrogen phosphate dihydrate,
  • Sugar
    – sucrose

The vaccine contains less than 1 mmol (39 mg) of potassium per dose, i.e. it is considered essentially ‘potassium-free’. It also contains less than 1 mmol sodium (23 mg) per dose, so is considered essentially ‘sodium-free’.